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| * '''Description:''' pyrimidine nucleoside phosphorylase <br/><br/>
| | {{#bank: Pdp}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''pdp''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || pyrimidine nucleoside phosphorylase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || pyrimidine interconversion
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU39400 pdp]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/nucleosides_catabolism.html Nucleoside catabolism], [http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 46 kDa, 4.765
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1299 bp, 433 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hutM]]'', ''[[nupC]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU39400 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU39400 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU39400 DNA_with_flanks]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:pdp_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pdp_4049009_4050310_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:pdp_expression.png|500px]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[utilization of nucleotides]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CcpA regulon]]}},
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| {{SubtiWiki regulon|[[DeoR regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU39400
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/deoR-dra-nupC-pdp.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10985]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' A pyrimidine nucleoside + phosphate = a pyrimidine base + alpha-D-ribose 1-phosphate (according to Swiss-Prot)
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| * '''Protein family:''' thymidine/pyrimidine-nucleoside phosphorylase family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1BRW 1BRW] (Geobacillus stearothermophilus)
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P39142 P39142]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU39400]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/2.4.2.2 2.4.2.2]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[dra]]-[[nupC]]-[[pdp]]'' {{PubMed|8550462}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pdp_4049009_4050310_-1 pdp] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|8550462}}
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| * '''Regulation:'''
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| ** repressed by glucose ([[CcpA]]) {{PubMed|10666464}}
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| ** induced by deoxynucleotides ([[DeoR]]) {{PubMed|8550462}}
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| * '''Regulatory mechanism:'''
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| ** [[CcpA]]: transcription repression {{PubMed|10666464}}
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| ** [[DeoR]]: transcription repression {{PubMed|8550462}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>,11065368,8550462,10074062, 10666464 </pubmed>
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| [[Category:Protein-coding genes]]
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