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| * '''Description:''' stimulates poly-gamma-glutamate production in the presence of zinc, also involved in extra-chromosomal DNA maintenance<br/><br/>
| | {{#bank: CapE}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''capE''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ywtC, pgsE, edmS''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || unknown
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| |style="background:#ABCDEF;" align="center"|'''Function''' || capsule synthesis
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU35870 capE]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 6 kDa, 6.487
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 165 bp, 55 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[pgdS]]'', ''[[capA]]''
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| |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU35870 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU35870 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU35870 Advanced_DNA]
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ywtC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pgsE_3697639_3697806_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:capE_expression.png|500px]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[capsule biosynthesis and degradation]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[DegU regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU35870
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ywsC-ywtABC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12534]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** stimulates poly-gamma-glutamate production in the presence of zinc {{PubMed|20812257}}
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| ** also involved in extra-chromosomal DNA maintenance {{PubMed|23583563,21357437}}
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:''' N-terminal membrane-anchoring domain and a C-terminal assembly accelerator-like structure {{PubMed|23583563}}
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** cell membrane {{PubMed|23583563}}
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P96739 P96739]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU35870]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[capB]]-[[capC]]-[[capA]]-[[capE]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/11751809 PubMed]
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=pgsE_3697639_3697806_-1 capE] {{PubMed|22383849}}
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| * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/19420703 PubMed]
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| * '''Regulation:'''
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| * '''Regulatory mechanism:''' activated by [[DegU]]-P [http://www.ncbi.nlm.nih.gov/sites/entrez/19420703 PubMed]
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| * '''Additional information:''' The operon is not expressed in the lab strain 168 due to lack of expression of [[DegQ]] resulting in inactivity of [[DegS]] and [[DegU]] {{PubMed|21965392}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>19420703, 16233197 16267300 20564357 20564574 21357437 23583563 20812257,21965392</pubmed>
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| [[Category:Protein-coding genes]]
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