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| * '''Description:''' maybe involved in the synthesis of c-di-AMP in vegetative cells<br/><br/>
| | {{#bank: CdaA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''ybbP''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ybbQ ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || unknown
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || unknown
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| |-
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU01750 ybbP]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/murein/index.html Murein recycling]'''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 8.074
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 819 bp, 273 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ybbM]]'', ''[[ybbR]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11951]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ybbP_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ybbP_196213_197034_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:ybbP_expression.png|500px]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[membrane proteins]]}},
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| {{SubtiWiki category|[[metabolism of signalling nucleotides]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU01750
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| ===Phenotypes of a mutant ===
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| * inactivation of ''[[ybbP]]'' results in severe beta-lactam sensitivity {{PubMed|22211522}}
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| === Database entries ===
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11577]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):''' [[YojJ]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:''' contains a DAC domain potentially involved in the synthesis of c-di-AMP {{PubMed|21566650}}
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| ** cell membrane (according to Swiss-Prot)
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/Q45589 Q45589]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU01750]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[ybbP]]-[[ybbR]]-[[glmM]]-[[glmS]]''
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ybbP_196213_197034_1 ybbP] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|22211522}}
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:''' the ''[[ybbP]]-[[ybbR]]'' part of the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
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| =Biological materials =
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| * '''Mutant:'''
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| ** GP997 (''[[ybbP]]''::''cat''), available in [[Jörg Stülke]]'s lab
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| ** GP985 (''[[ybbP]]''-''[[ybbR]]''::''cat''), available in [[Jörg Stülke]]'s lab
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| * '''Expression vector:'''
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| ** expression of native ''ybbP'' in ''B. subtilis'': pGP1960 (in [[pBQ200]]), available in [[Jörg Stülke]]'s lab
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| ** expression of ''ybbP''-Strep in ''B. subtilis'' suitable for [[SPINE]]: pGP1986 (in [[pGP382]]), available in [[Jörg Stülke]]'s lab
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| * '''lacZ fusion:''' GP1339 (cat) based on [[pAC6]], available in [[Jörg Stülke]]'s lab
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| * '''GFP fusion:'''
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| * '''two-hybrid system:''' B. pertussis adenylate cyclase-based bacterial two hybrid system ([[BACTH]]), available in [[Jörg Stülke]]'s lab. Respective plasmid: pGP1990.
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| * '''FLAG-tag construct:'''
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| ** GP1331 (''[[ybbP]]''-3xFLAG ''ermC'', based on [[pGP1087]]), available in [[Jörg Stülke]]'s lab
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 18714086</pubmed>
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| ==Original publications==
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| '''Additional publications:''' {{PubMed|22211522}}
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| <pubmed>12884008,21566650, </pubmed>
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| [[Category:Protein-coding genes]]
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