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| * '''Description:''' protein deacetylase for the control of [[AcsA]] activity <br/><br/>
| | {{#bank: AcuC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''acuC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[AcsA]] deacetylase
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[AcsA]] activity
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU29710 acuC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 42 kDa, 5.062
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1161 bp, 387 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[acuB]]'', ''[[motS]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14949]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:acuC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=acuC_3041392_3042555_1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:acuC_expression.png|500px]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[utilization of specific carbon sources]]}},
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| {{SubtiWiki category|[[utilization of lipids]]}},
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| {{SubtiWiki category|[[protein modification]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CcpA regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU29710
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/acuABC.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10367]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' deacetylates (and thereby activates) [[AcsA]] (together with [[SrtN]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/19136592 PubMed]
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| * '''Protein family:''' histone deacetylase family (according to Swiss-Prot) class I histone deacetylase
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P39067 P39067]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU29710]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[acuA]]-[[acuB]]-[[acuC]]'' {{PubMed|7934817}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=acuC_3041392_3042555_1 acuC] {{PubMed|22383849}}
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| * '''Sigma factor:''' [[SigA]] {{PubMed|7913927}}
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| * '''Regulation:'''
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| ** repressed by glucose ([[CcpA]]) {{PubMed|7913927,12850135}}
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| * '''Regulatory mechanism:'''
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| ** [[CcpA]]: transcription repression {{PubMed|7913927}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| ** GP1209 (''[[acuC]]''::''kan''), available in [[Stülke]] lab
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| ** GP1213 (''[[srtN]]''::''cat'')(''[[acuC]]''::''kan''), available in [[Stülke]] lab
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>7913927,,16855235,7934817, 19136592, 18487328 </pubmed>
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| [[Category:Protein-coding genes]]
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