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| * '''Description:''' write here <br/><br/>
| | {{#bank: Icd}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''icd''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''citC ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || isocitrate dehydrogenase (EC 1.1.1.42)
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| |style="background:#ABCDEF;" align="center"|'''Function''' ||
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 46 kDa, 4.833
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1269 bp, 423 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' ||
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/icd_nucleotide.txt Gene sequence (+200bp) ]'''
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| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/icd_protein.txt Protein sequence]'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:icd_context.gif]]
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| |}
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| __TOC__
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| <br/><br/>
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| =The gene=
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| === Basic information ===
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| * '''Coordinates:'''
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/icd.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10856]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''Interactions:'''
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| * '''Localization:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''Swiss prot entry:'''
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| * '''KEGG entry:'''
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| **''[[citZ]]-[[icd]]-[[mdh]]''
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| **''[[icd]]-[[mdh]]''
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| * '''Sigma factor:''' [[SigA]]
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| * '''Regulation:''' catabolite repression ([[CcpA]]), repression by glucose + glutamate ([[CcpC]])
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| ''[[icd]]'': constitutive
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| * '''Regulatory mechanism:''' [[CcpA]]: transcription repression, [[CcpC]]: transcription repression
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| # Matsuno K, Blais T, Serio AW, Conway T, Henkin TM, Sonenshein AL (1999) Metabolic imbalance and sporulation in an isocitrate dehydrogenase mutant of Bacillus subtilis. J Bacteriol 181:3382-3391. [http://www.ncbi.nlm.nih.gov/sites/entrez/10348849 PubMed]
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| # Singh SK, Miller SP, Dean A, Banaszak LJ, LaPorte DC (2002) Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/ phosphatase. J Biol Chem 277: 7567-7573. [http://www.ncbi.nlm.nih.gov/sites/entrez/11751849 PubMed]
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| # Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]
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