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| * '''Description:''' fructosamine kinase <br/><br/>
| | {{#bank: FrlD}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''frlD''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yurL ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || fructosamine kinase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || metabolism of sugar amines
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/other_nitrogen_sources/index.html Alternative nitrogen sources]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 4.909
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 852 bp, 284 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[frlR]]'', ''[[frlM]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB15247]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:yurL_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |-
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| |}
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| __TOC__
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| <br/><br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[utilization of specific carbon sources]]}},
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| {{SubtiWiki category|[[utilization of nitrogen sources other than amino acids]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CodY regulon]]}}, {{SubtiWiki regulon|[[FrlR regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU32570
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yurRQPONML.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13998]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' carbohydrate kinase pfkB family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/O32153 O32153]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU32570]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[yurR]]-[[yurQ]]-[[frlB]]-[[frlO]]-[[frlN]]-[[frlM]]-[[frlD]]'' {{PubMed|12823818}}
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| ** ''[[frlB]]-[[frlO]]-[[frlN]]-[[frlM]]-[[frlD]]'' {{PubMed|21347729}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=frlD_3347051_3347905_-1 frlD] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| **'' [[frlB]]'': repressed during growth in the presence of branched chain amino acids ([[CodY]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed]
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| ** ''[[frlB]]'': induced in the presence of fructosamine ([[FrlR]]) {{PubMed|21397556}}
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| * '''Regulatory mechanism:'''
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| ** [[CodY]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/12618455 PubMed1], [http://www.ncbi.nlm.nih.gov/sites/entrez/18083814 PubMed2]
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| ** [[FrlR]]: transcription repression {{PubMed|21397556}}
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| * '''Additional information:'''
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| ** the mRNA is substantially stabilized upon depletion of [[Rny|RNase Y]] {{PubMed|21815947}}
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| '''Additional references:''' {{PubMed|21397556}}
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| <big>''Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J'' </big>
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| <big>'''RNA processing in ''Bacillus subtilis'': identification of targets of the essential RNase Y.''' </big>
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| <big>Mol Microbiol. 2011 81(6): 1459-1473. </big>
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| [http://www.ncbi.nlm.nih.gov/pubmed/21815947 PubMed:21815947]
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| <pubmed>15556630,16153181, 21347729,12618455, 12823818, 21398478</pubmed>
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| [[Category:Protein-coding genes]]
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