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| * '''Description:''' [[cytochrome P450]] enzyme <br/><br/>
| | {{#bank: BioI}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''bioI''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || [[cytochrome P450]] enzyme
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| |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of biotin
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/BioI BioI]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biotin/index.html Biotin]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 44 kDa, 6.2
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1185 bp, 395 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ytbQ]]'', ''[[bioB]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14997]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:bioI_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bioI_3089226_3090413_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:bioI_expression.png|500px]]
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| |}
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| __TOC__
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/><br/><br/>
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[biosynthesis of cofactors]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[BirA regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU30190
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/bioWAFDBI-ytbQ.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG11528]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' formation of pimelic acid via a multiple-step oxidative cleavage of long-chain fatty acids
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| * '''Protein family:''' [[cytochrome P450]] family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[Fer]]-[[BioI]] {{PubMed|12538057}}
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| ** [[YkuP]]-[[BioI]] {{PubMed|15449930}}
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| ** [[AcpA]]-[[BioI]] {{PubMed|18838690}}
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| * '''[[Localization]]:'''
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| === Database entries ===
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| * '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=3EJB 3EJB], [http://www.rcsb.org/pdb/explore.do?structureId=3EJE 3EJE] (complex with [[AcpA]]) {{PubMed|18838690}}
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P53554 P53554]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU30190]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[bioW]]-[[bioA]]-[[bioF]]-[[bioD]]-[[bioB]]-[[bioI]]-[[ytbQ]]'' {{PubMed|8763940,8892842}}
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bioI_3089226_3090413_-1 bioI] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| ** repressed in the presence of biotin ([[BirA]]) {{PubMed|8763940,8892842}}
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| * '''Regulatory mechanism:'''
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| ** [[BirA]]: transcription repression {{PubMed|8763940,8892842}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews: {{PubMed|21437340}}==
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| ==Original publications==
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| <pubmed> 18838690 ,8763940,8892842,15449931, 15449930 12538057 20658980 11368323 11472016 14737344 12943422 </pubmed>
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| [[Category:Protein-coding genes]]
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