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| * '''Description:''' DNA translocase <br/><br/>
| | {{#bank: SftA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''sftA''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ytpS, cdtA ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || DNA translocase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || resolution of chromosome dimers
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 107 kDa, 5.052
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 2856 bp, 952 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[murC]]'', ''[[ytpR]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14959]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:ytpS_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |-
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| |}
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| __TOC__
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[DNA condensation/ segregation]]}}
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| = This gene is a member of the following [[regulons]] =
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU29805
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' no entry
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13906]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| ** aids in moving DNA away from the closing septum, binds DNA, DNA-dependent ATPase activity {{PubMed|19818024}}
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| ** the two DNA translocases [[SftA]] and [[SpoIIIE]] synergistically affect chromosome dimer resolution presumably by positioning the dif sites in close proximity, before or after completion of cell division, respectively {{PubMed|21239579}}
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| * '''Protein family:'''
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| * '''Paralogous protein(s):''' [[SpoIIIE]]
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** forms a hexamer {{PubMed|19818024}}
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| * '''[[Localization]]:'''
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| ** Cytoplasm (Homogeneous) [http://www.ncbi.nlm.nih.gov/sites/entrez/16479537 PubMed]
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| ** co-localizes with [[FtsZ]] at nascent division sites {{PubMed|19788545}}
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/C0SP86 C0SP86]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU29810]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ytpS_3049725_3052583_-1 sftA] {{PubMed|22383849}}
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| * '''Sigma factor:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| ==Reviews==
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| <pubmed> 22047950 </pubmed>
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| ==Original publications==
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| <pubmed>16479537 19788545 19818024 21239579</pubmed>
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| [[Category:Protein-coding genes]]
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