|
|
| (100 intermediate revisions by 11 users not shown) |
| Line 1: |
Line 1: |
| * '''Description:''' write here <br/><br/>
| | {{#bank: Icd}} |
|
| |
|
| {| align="right" border="1" cellpadding="2"
| |
| |-
| |
| |style="background:#ABCDEF;" align="center"|'''Gene name'''
| |
| |''icd''
| |
| |-
| |
| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''citC ''
| |
| |-
| |
| |style="background:#ABCDEF;" align="center"| '''Essential''' ||
| |
| |-
| |
| |style="background:#ABCDEF;" align="center"| '''Product''' || isocitrate dehydrogenase (EC 1.1.1.42)
| |
| |-
| |
| |style="background:#ABCDEF;" align="center"|'''Function''' ||
| |
| |-
| |
| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 46 kDa, 4.833
| |
| |-
| |
| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1269 bp, 423 aa
| |
| |-
| |
| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' ||
| |
| |-
| |
| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/icd_nucleotide.txt Gene sequence (+200bp) ]'''
| |
| |style="background:#FAF8CC;" align="center"|'''[http://subtiwiki.uni-goettingen.de/icd_protein.txt Protein sequence]'''
| |
| |-
| |
| |colspan="2" | '''Genetic context''' <br/> [[Image:icd_context.gif]]
| |
| |-
| |
| |}
| |
|
| |
| __TOC__
| |
|
| |
| <br/><br/>
| |
|
| |
| =The gene=
| |
|
| |
| === Basic information ===
| |
|
| |
| * '''Coordinates:'''
| |
|
| |
| ===Phenotypes of a mutant ===
| |
|
| |
| === Database entries ===
| |
|
| |
| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/icd.html]
| |
|
| |
| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10856]
| |
|
| |
| === Additional information===
| |
|
| |
|
| |
| =The protein=
| |
|
| |
| === Basic information/ Evolution ===
| |
|
| |
| * '''Catalyzed reaction/ biological activity:'''
| |
|
| |
| * '''Protein family:'''
| |
|
| |
| * '''Paralogous protein(s):'''
| |
|
| |
| === Extended information on the protein ===
| |
|
| |
| * '''Kinetic information:'''
| |
|
| |
| * '''Domains:'''
| |
|
| |
| * '''Modification:'''
| |
|
| |
| * '''Cofactor(s):'''
| |
|
| |
| * '''Effectors of protein activity:'''
| |
|
| |
| * '''Interactions:'''
| |
|
| |
| * '''Localization:'''
| |
|
| |
| === Database entries ===
| |
|
| |
| * '''Structure:'''
| |
|
| |
| * '''Swiss prot entry:'''
| |
|
| |
| * '''KEGG entry:'''
| |
|
| |
| * '''E.C. number:'''
| |
|
| |
| === Additional information===
| |
|
| |
| =Expression and regulation=
| |
|
| |
| * '''Operon:'''
| |
| **''[[citZ]]-[[icd]]-[[mdh]]''
| |
| **''[[icd]]-[[mdh]]''
| |
|
| |
| * '''Sigma factor:''' [[SigA]]
| |
|
| |
| * '''Regulation:''' catabolite repression ([[CcpA]]), repression by glucose + glutamate ([[CcpC]])
| |
|
| |
| * '''Regulatory mechanism:''' [[CcpA]]: transcription repression, [[CcpC]]: transcription repression
| |
|
| |
| * '''Additional information:'''
| |
|
| |
| =Biological materials =
| |
|
| |
| * '''Mutant:'''
| |
|
| |
| * '''Expression vector:'''
| |
|
| |
| * '''lacZ fusion:'''
| |
|
| |
| * '''GFP fusion:'''
| |
|
| |
| * '''two-hybrid system:'''
| |
|
| |
| * '''Antibody:'''
| |
|
| |
| =Labs working on this gene/protein=
| |
|
| |
| =Your additional remarks=
| |
|
| |
| =References=
| |
|
| |
| # Matsuno K, Blais T, Serio AW, Conway T, Henkin TM, Sonenshein AL (1999) Metabolic imbalance and sporulation in an isocitrate dehydrogenase mutant of Bacillus subtilis. J Bacteriol 181:3382-3391. [http://www.ncbi.nlm.nih.gov/sites/entrez/10348849 PubMed]
| |
| # Singh SK, Miller SP, Dean A, Banaszak LJ, LaPorte DC (2002) Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/ phosphatase. J Biol Chem 277: 7567-7573. [http://www.ncbi.nlm.nih.gov/sites/entrez/11751849 PubMed]
| |
| # Author1, Author2 & Author3 (year) Title ''Journal'' '''volume:''' page-page. [http://www.ncbi.nlm.nih.gov/sites/entrez/PMID PubMed]
| |
