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| Biofilms are the result of the multicellular lifestyle of ''B. subtilis''. They are characterized by the formation of a matrix polysaccharide and an amyloid-like protein, [[TasA]].
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''sinR''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''sin, flaD ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional regulator of post-exponential-phase responses genes
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| |-
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| |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[biofilm formation]]
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm], [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]'''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 7.177
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 333 bp, 111 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sinI]]'', ''[[tasA]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14392]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:sinR_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |}
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| __TOC__
| | [[File:Example.jpg]] |
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| ==[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm formation in ''Subti''Pathways]==
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| ==Labs working on biofilm formation==
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| * [[Daniel Kearns]]
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| * [[Oscar Kuipers]]
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| * [[Beth Lazazzera]]
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| * [[Richard Losick]]
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| * [[Nicola Stanley-Wall]]
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| ==Key genes and operons involved in biofilm formation==
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| * matrix polysaccharide synthesis:
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| ** ''[[epsA]]-[[epsB]]-[[epsC]]-[[epsD]]-[[epsE]]-[[epsF]]-[[epsG]]-[[epsH]]-[[epsI]]-[[epsJ]]-[[epsK]]-[[epsL]]-[[epsM]]-[[epsN]]-[[epsO]]''
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| * amyloid protein synthesis
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| ** ''[[yqxM]]-[[sipW]]-[[tasA]]''
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| * regulation
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| ** [[SlrR]]
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| ** [[SlrA]]
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| ** [[SinR]]
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| ** [[SinI]]
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| ** [[PtkA]]
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| ** [[TkmA]]
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| ** [[PtpZ]]
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| ** [[DegU]]
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| ** [[RacX]]
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| * biofilm disassembly
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| ** [[YlmE]]
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| * other proteins required for biofilm formation
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| ** [[SpeA]]
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| ** [[YmcA]]
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| ** [[YxaB]]
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| ==Key reviews==
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| <pubmed>19054118 19054118 16787201 9891794 20890834 </pubmed>
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| * additional reviews: {{PubMed|20735481}}
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