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| * '''Description:''' RNA polymerase [[sigma factor]] SigD <br/><br/>
| | {{#bank: SigD}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''sigD''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''flaB ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || RNA polymerase [[sigma factor]] SigD
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| |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of flagella, motility, chemotaxis and autolysis
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.167
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 762 bp, 254 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[cheD]]'', ''[[swrB]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13520]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:sigD_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |}
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| __TOC__
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| <br/><br/>
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU16470
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/fla-che.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10751]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' sigma-70 factor family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Genes/ operons controlled by SigD ===
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| ''[[dltA]]-[[dltB]]-[[dltC]]-[[dltD]]-[[dltE]]'', ''[[cheV]]'', ''[[degR]]'', ''[[epr]]'', ''[[hag]]'', ''[[lytA]]-[[lytB]]-[[lytC]]'', ''[[lytD]]'', ''[[lytF]]'', ''[[tlpA]]-[[mcpA]]'', ''[[mcpB]]'', ''[[mcpC]]'', ''[[motA]]-[[motB]]'', ''[[nfrA]]-[[ywcH]]''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''Interactions:''' [[SigD]]-[[FlgM]]
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| * '''Localization:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P10726 P10726]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU16470]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[flgB]]-[[flgC]]-[[fliE]]-[[fliF]]-[[fliG]]-[[fliH]]-[[fliI]]-[[fliJ]]-[[ylxF]]-[[fliK]]-[[ylxG]]-[[flgE]]-[[fliL]]-[[fliM]]-[[fliY]]-[[cheY]]-[[fliZ]]-[[fliP]]-[[fliQ]]-[[fliR]]-[[flhB]]-[[flhA]]-[[flhF]]-[[ylxH]]-[[cheB]]-[[cheA]]-[[cheW]]-[[cheC]]-[[cheD]]-[[sigD]]-[[swrB]]'' {{PubMed|9657996,8157612,15175317}}
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| ** ''[[sigD]]-[[swrB]]'' {{PubMed|9335309}}
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| * '''[[Sigma factor]]:'''
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| ** ''[[flgB]]'': [[SigA]] {{PubMed|9657996}}, [[SigD]] {{PubMed|9657996}}
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| ** ''[[sigD]]'': [[SigA]] {{PubMed|9335309}}
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| * '''Regulation:'''
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| ** ''[[flgB]]'' promoter: repressed under conditions that trigger sporulation ([[Spo0A]]) {{PubMed|14651647}}
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| * '''Regulatory mechanism:'''
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| ** [[Spo0A]]: transcription repression {{PubMed|14651647}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:''' B. pertussis adenylate cyclase-based bacterial two hybrid system ([[BACTH]]), available in [[Stülke]] lab
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>8955328,7708689,15033535,9648743,8169223,9096206,15175317,2498284,16357223,3127378,9144176,18820022,2111808,7602586,2832368,8195064,11987133,,14651647, 9335309 9657996,8157612,15175317 </pubmed>
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| [[Category:Protein-coding genes]]
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