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| * '''Description:''' 1-pyrroline-5-carboxylate dehydrogenase <br/><br/>
| | {{#bank: ProG}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''proG''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ykeA, yzcA ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || 1-pyrroline-5-carboxylate dehydrogenase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of proline
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/proline.html Pro], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 30 kDa, 4.914
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 816 bp, 272 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[htrA]]'', ''[[dppA]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB13148]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:proG_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |}
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| __TOC__
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| <br/><br/><br/><br/><br/><br/>
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU12910
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/proG.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10841]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' L-proline + NAD(P)<sup>+</sup> = 1-pyrroline-5-carboxylate + NAD(P)H (according to Swiss-Prot)
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| * '''Protein family:''' pyrroline-5-carboxylate reductase family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''Interactions:'''
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| * '''Localization:''' cytoplasm (according to Swiss-Prot)
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/Q00777 Q00777]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU12910]
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| * '''E.C. number:''' [http://www.expasy.org/enzyme/1.5.1.2 1.5.1.2]
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''proG'' {{PubMed|1766370}}
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| * '''[[Sigma factor]]:'''
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| * '''Regulation:'''
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>,11418582, 1766370 </pubmed>
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| [[Category:Protein-coding genes]]
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