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* '''Description:''' ribonucleoside-diphosphate reductase <br/><br/>
{{#bank: nrdI}}
* '''Description:''' flavodoxin, ribonucleoside-diphosphate reductase <br/><br/>


{| align="right" border="1" cellpadding="2"  
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"|'''Function''' || synthesis of deoxyribonucleoside triphosphates
|style="background:#ABCDEF;" align="center"|'''Function''' || synthesis of deoxyribonucleoside triphosphates
|-
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/gene_regulation_nucleotides.html Nucleotides (regulation)]'''
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU17370 nrdI]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=NrdI NrdI]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=nrdI nrdI]'''
|-
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 8.58   
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 8.58   
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|colspan="2" | '''Genetic context''' <br/> [[Image:ymaA_context.gif]]
|colspan="2" | '''Genetic context''' <br/> [[Image:ymaA_context.gif]]
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
  <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=nrdI_1868617_1869009_1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:nrdI_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU17370]]
|-
|-
|}
|}


__TOC__
__TOC__
<br/><br/><br/><br/>
<br/><br/><br/><br/>
<br/><br/><br/><br/>
<br/><br/>
= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[biosynthesis/ acquisition of nucleotides]]}},
{{SubtiWiki category|[[essential genes]]}}


<br/><br/>
= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ResD regulon]]}}


=The gene=
=The gene=
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=== Database entries ===
=== Database entries ===
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU17370&redirect=T BSU17370]


* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/nrdIEF-ymaB.html]
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/nrdIEF-ymaB.html]
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=== Additional information===
=== Additional information===


=The protein=
=The protein=
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* '''Protein family:''' nrdI family (according to Swiss-Prot)
* '''Protein family:''' nrdI family (according to Swiss-Prot)


* '''Paralogous protein(s):'''
* '''Paralogous protein(s):''' [[YosM]]


=== Extended information on the protein ===
=== Extended information on the protein ===
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* '''Effectors of protein activity:'''
* '''Effectors of protein activity:'''


* '''Interactions:'''
* '''[[SubtInteract|Interactions]]:'''
** [[NrdI]]-[[NrdF]] {{PubMed|23402532}}


* '''Localization:'''
* '''[[Localization]]:'''


=== Database entries ===
=== Database entries ===
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU17370&redirect=T BSU17370]


* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1RLJ 1RLJ]
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=1RLJ 1RLJ]


* '''Swiss prot entry:''' [http://www.uniprot.org/uniprot/P50618 P50618]
* '''UniProt:''' [http://www.uniprot.org/uniprot/P50618 P50618]


* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu+BSU17370]
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU17370]


* '''E.C. number:'''
* '''E.C. number:'''
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=Expression and regulation=
=Expression and regulation=


* '''Operon:''' ''[[nrdI]]-[[nrdE]]-[[nrdF]]-[[ymaB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/16885274 PubMed]
* '''Operon:''' ''[[nrdI]]-[[nrdE]]-[[nrdF]]-[[ymaB]]'' {{PubMed|16885274}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=nrdI_1868617_1869009_1 nrdI] {{PubMed|22383849}}


* '''[[Sigma factor]]:'''  
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|16885274}}


* '''Regulation:''' distinct promoters for aerobic and anaerobic expression [http://www.ncbi.nlm.nih.gov/sites/entrez/16885274 PubMed], anaerobic expression requires [[ResD]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16885274 PubMed]
* '''Regulation:'''  
** expressed under anaerobic conditions ([[ResD]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/16885274 PubMed]
** expressed under anaerobic conditions ([[ResD]]) {{PubMed|16885274}}


* '''Regulatory mechanism:''' [[ResD]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/16885274 PubMed]
* '''Regulatory mechanism:'''  
** [[ResD]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/16885274 PubMed]
** [[ResD]]: transcription activation {{PubMed|16885274}}


* '''Additional information:'''
* '''Additional information:'''
** A [[ncRNA]] is predicted between ''[[ymzA]]'' and ''[[nrdI]]'' {{PubMed|20525796}}


=Biological materials =
=Biological materials =
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=References=
=References=
==Reviews==
<pubmed> 17229208 </pubmed>
==Original Publications==
'''Additional publications:''' {{PubMed|23402532}}
<pubmed>16885274,8969495, 12682299 ,20525796</pubmed>


<pubmed>16885274,8969495,,16885274, </pubmed>
[[Category:Protein-coding genes]]

Latest revision as of 09:54, 7 December 2016

nrdI

  • Description: flavodoxin, ribonucleoside-diphosphate reductase

Gene name nrdI
Synonyms ymaA
Essential yes PubMed
Product ribonucleoside-diphosphate reductase
Function synthesis of deoxyribonucleoside triphosphates
Gene expression levels in SubtiExpress: nrdI
Interactions involving this protein in SubtInteract: NrdI
Metabolic function and regulation of this protein in SubtiPathways:
nrdI
MW, pI 14 kDa, 8.58
Gene length, protein length 390 bp, 130 aa
Immediate neighbours ymzA, nrdE
Gene sequence (+200bp) Protein sequence
Genetic context
This image was kindly provided by SubtiList
Expression at a glance   PubMed















Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, essential genes

This gene is a member of the following regulons

ResD regulon

The gene

Basic information

  • Locus tag: BSU17370

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: nrdI family (according to Swiss-Prot)
  • Paralogous protein(s): YosM

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under anaerobic conditions (ResD) PubMed
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

<pubmed> 17229208 </pubmed>

Original Publications

Additional publications: PubMed <pubmed>16885274,8969495, 12682299 ,20525796</pubmed>

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