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| * '''Description:''' ATP-dependent deoxyribonuclease (subunit A) <br/><br/>
| | {{#bank: AddA}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''addA''
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''recE5 ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || no
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| |style="background:#ABCDEF;" align="center"| '''Product''' || ATP-dependent deoxyribonuclease (subunit A))
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| |style="background:#ABCDEF;" align="center"|'''Function''' || DNA repair and recombination
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 140 kDa, 5.127
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 3696 bp, 1232 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[addB]]'', ''[[sbcD]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB12903]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:addA_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |}
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| __TOC__
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| <br/><br/>
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU10630
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| ===Phenotypes of a mutant ===
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/addBA.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10466]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:'''
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| * '''Protein family:''' uvrD-like helicase C-terminal domain (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''Interactions:'''
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| * '''Localization:'''
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P23478 P23478]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU10630]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:''' ''[[addB]]-[[addA]]'' {{PubMed|1646786}}
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| * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|7746142}}
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| * '''Regulation:'''
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| ** positive control by [[ComK]] {{PubMed|7746142}}
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| * '''Regulatory mechanism:'''
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:''' GP1106 (addAB, spc), available in [[Stülke]] lab
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>,8387145,15610857,7746142, 19129187 15009890 10756102 9781875 16632468 </pubmed>
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| [[Category:Protein-coding genes]]
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