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| * '''Description:''' cell-division initiation protein (septum formation), component of septosome (with [[DivIB]]) <br/><br/>
| | {{#bank: DivIC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''divIC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Product''' || cell-division protein
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| |style="background:#ABCDEF;" align="center"|'''Function''' || septum formation
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| |colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://cellpublisher.gobics.de/subtinteract/startpage/start/ ''Subt''Interact]''': [http://cellpublisher.gobics.de/subtinteract/interactionList/2/DivIC DivIC]
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 14 kDa, 9.968
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 375 bp, 125 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yabQ]]'', ''[[yabR]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB11838]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:divIC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |-
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| |}
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| __TOC__
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[cell division]]}},
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| {{SubtiWiki category|[[sporulation proteins]]}},
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| {{SubtiWiki category|[[cell envelope stress proteins (controlled by SigM, W, X, Y)]]}},
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| {{SubtiWiki category|[[essential genes]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[SigE regulon]]}},
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| {{SubtiWiki regulon|[[SigM regulon]]}},
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| {{SubtiWiki regulon|[[SigW regulon]]}},
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| {{SubtiWiki regulon|[[SigX regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU00620
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| ===Phenotypes of a mutant ===
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| essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/yabMNOPQ-divIC-yabR.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10125]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' stabilizes [[FtsL]] against [[RasP]] cleavage {{PubMed|20644139}}
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| * '''Protein family:'''
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''[[SubtInteract|Interactions]]:'''
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| ** [[DivIC]]-[[FtsL]] {{PubMed|10844672}}
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| ** [[PbpB]]-[[DivIB]]-([[FtsL]]-[[DivIC]])2 {{PubMed|20870765}}, as part of the [[divisome]]
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| * '''[[Localization]]:''' membrane bound [http://www.ncbi.nlm.nih.gov/sites/entrez/9426141 PubMed]
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P37471 P37471]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU00620]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon:'''
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| ** ''[[yabM]]-[[yabN]]-[[yabO]]-[[yabP]]-[[yabQ]]-[[divIC]]-[[yabR]]'' {{PubMed|11283287}}
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| ** ''[[yabP]]-[[yabQ]]-[[divIC]]-[[yabR]]'' {{PubMed|11283287}}
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| ** ''[[divIC]]-[[yabR]]'' {{PubMed|11283287}}
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| * '''[[Sigma factor]]:'''
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| ** ''[[yabM]]'': unknown
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| ** ''[[yabP]]'': [[SigE]] {{PubMed|11283287}}
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| ** ''[[divIC]]'': [[SigM]] [http://www.ncbi.nlm.nih.gov/sites/entrez/18179421 PubMed], [[SigX]] {{PubMed|12207695}}, [[SigW]] {{PubMed|12207695}}
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| * '''Regulation:''' expressed during sporulation ([[SigE]]) {{PubMed|11283287}} and under stress conditions
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| * '''Regulatory mechanism:'''
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| * '''Additional information:''' there are about 50,000 molecules of DivIC per cell [http://www.ncbi.nlm.nih.gov/sites/entrez/9426141 PubMed]
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>18179421,16936019,10217758,9720875,8113187,10323866,9426141,10852898,10844672,11283287 , 11994149, 20644139</pubmed>
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| '''Additional publications:''' {{PubMed|20870765}}
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| [[Category:Protein-coding genes]]
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