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| * '''Description:''' part of heam translocase, required for cytochrome c synthesis <br/><br/>
| | {{#bank: ResC}} |
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| {| align="right" border="1" cellpadding="2"
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| |style="background:#ABCDEF;" align="center"|'''Gene name'''
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| |''resC''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''ypxC ''
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| |-
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| |style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| |style="background:#ABCDEF;" align="center"| '''Product''' || part of the [[ResB]]-[[ResC]] haem translocase
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| |style="background:#ABCDEF;" align="center"|'''Function''' || cytochrome c biogenesis
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| |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 39 kDa, 9.564
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| |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 1056 bp, 352 aa
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| |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[resD]]'', ''[[resB]]''
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| |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14245]+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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| |colspan="2" | '''Genetic context''' <br/> [[Image:resC_context.gif]]
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| <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
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| |-
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| |}
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| __TOC__
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| <br/><br/>
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| = [[Categories]] containing this gene/protein =
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| {{SubtiWiki category|[[respiration]]}},
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| {{SubtiWiki category|[[essential genes]]}},
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| {{SubtiWiki category|[[membrane proteins]]}}
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| = This gene is a member of the following [[regulons]] =
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| {{SubtiWiki regulon|[[CcpA regulon]]}},
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| {{SubtiWiki regulon|[[PhoP regulon]]}},
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| {{SubtiWiki regulon|[[ResD regulon]]}}
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| =The gene=
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| === Basic information ===
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| * '''Locus tag:''' BSU23130
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| ===Phenotypes of a mutant ===
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| essential [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]
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| === Database entries ===
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| * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/resABCDE.html]
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| * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10533]
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| === Additional information===
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| =The protein=
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| === Basic information/ Evolution ===
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| * '''Catalyzed reaction/ biological activity:''' haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane {{PubMed|19682263}}
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| * '''Protein family:''' ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)
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| * '''Paralogous protein(s):'''
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| === Extended information on the protein ===
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| * '''Kinetic information:'''
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| * '''Domains:'''
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| * '''Modification:'''
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| * '''Cofactor(s):'''
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| * '''Effectors of protein activity:'''
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| * '''Interactions:''' [[ResB]]-[[ResC]] {{PubMed|19682263}}
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| * '''Localization:''' cytoplasma membrane {{PubMed|19682263}}
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| === Database entries ===
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| * '''Structure:'''
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| * '''UniProt:''' [http://www.uniprot.org/uniprot/P35162 P35162]
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| * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU23130]
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| * '''E.C. number:'''
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| === Additional information===
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| =Expression and regulation=
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| * '''Operon''': ''[[resA]]-[[resB]]-[[resC]]-[[resD]]-[[resE]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715 PubMed]
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| * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715 PubMed]
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| * '''Regulation:'''
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| ** expressed under anaerobic conditions ([[ResD]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
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| ** expressed under conditions of phosphate limitation ([[PhoP]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/9988472 PubMed]
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| ** repressed by glucose ([[CcpA]]) {{PubMed|16825793}}
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| * '''Regulatory mechanism:'''
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| ** [[ResD]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8631715,11222591 PubMed]
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| ** [[PhoP]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/9988472 PubMed]
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| ** [[CcpA]]: transcription repression {{PubMed|16825793}}
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| * '''Additional information:'''
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| =Biological materials =
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| * '''Mutant:'''
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| * '''Expression vector:'''
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| * '''lacZ fusion:'''
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| * '''GFP fusion:'''
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| * '''two-hybrid system:'''
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| * '''Antibody:'''
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| =Labs working on this gene/protein=
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| =Your additional remarks=
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| =References=
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| <pubmed>10844653, 19682263, 8631715,11222591,9988472,17706591 16825793</pubmed>
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| [[Category:Protein-coding genes]]
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