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* '''Description:''' DNA transport machinery, minor pseudopilin <br/><br/>
{{#bank: ComGD}}


{| align="right" border="1" cellpadding="2"
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''comGD''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || minor pseudopilin
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || [[genetic competence]], DNA uptake
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24700 comGD]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Interactions involving this protein in [http://subtiwiki.uni-goettingen.de/interact/ ''Subt''Interact]''': [http://subtiwiki.uni-goettingen.de/interact/index.php?protein=ComGD ComGD]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 15 kDa, 9.883 
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 429 bp, 143 aa
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[comGE]]'', ''[[comGC]]''
|-
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU24700 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU24700 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU24700 DNA_with_flanks]
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:comGD_context.gif]]
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comGD_2557252_2557683_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:comGD_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU24700]]
|-
|}
__TOC__
<br/><br/><br/><br/>
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<br/><br/>
= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[genetic competence]]}}
= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[ComK regulon]]}}
=The gene=
=== Basic information ===
* '''Locus tag:''' BSU24700
===Phenotypes of a mutant ===
=== Database entries ===
* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/comGABCDEFG-yqzE.html]
* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG10486]
=== Additional information===
=The protein=
=== Basic information/ Evolution ===
* '''Catalyzed reaction/ biological activity:'''
* '''Protein family:'''
* '''Paralogous protein(s):'''
=== Extended information on the protein ===
* '''Kinetic information:'''
* '''[[Domains]]:'''
* '''Modification:'''
* '''[[Cofactors]]:'''
* '''Effectors of protein activity:'''
* '''[[SubtInteract|Interactions]]:'''
** [[ComGB]]-[[ComGD]] {{PubMed|15083159}}
** [[ComC]]-[[ComGD]] {{PubMed|9723928}}
** [[ComGD]]-[[ComGG]] {{PubMed|24164455}}
** [[ComGD]]-[[ComGE]] {{PubMed|24164455}}
* '''[[Localization]]:'''
** associated to the membrane via [[ComGG]] {{PubMed|24164455}}
** cell surface [http://www.ncbi.nlm.nih.gov/pubmed/9723928 PubMed]
=== Database entries ===
* '''Structure:'''
* '''UniProt:''' [http://www.uniprot.org/uniprot/P25956 P25956]
* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU24700]
* '''E.C. number:'''
=== Additional information===
=Expression and regulation=
* '''Operon:''' ''[[comGA]]-[[comGB]]-[[comGC]]-[[comGD]]-[[comGE]]-[[comGF]]-[[comGG]]-[[yqzE]]'' {{PubMed|2507524}} 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=comGD_2557252_2557683_-1 comGD] {{PubMed|22383849}}
* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|2507524}}
* '''Regulation:'''
** repressed by casamino acids [http://www.ncbi.nlm.nih.gov/pubmed/12107147 PubMed] 
* '''Regulatory mechanism:'''
** [[ComK]]: transcription activation {{PubMed|8196543}}
* '''Additional information:'''
=Biological materials =
* '''Mutant:'''
* '''Expression vector:'''
       
* '''lacZ fusion:'''
* '''GFP fusion:'''
* '''two-hybrid system:'''
* '''Antibody:'''
=Labs working on this gene/protein=
=Your additional remarks=
=References=
==Reviews==
<pubmed> 15083159 </pubmed>
==Original publications==
<pubmed>9422590,9723928,11814663,,12107147, 2507524 8196543 24164455</pubmed>
[[Category:Protein-coding genes]]

Latest revision as of 11:45, 8 April 2014