View source for SnaA

* '''Description:''' sulphur N-acetylase, required for the conversion of S-methyl-cysteine to cysteine <br/><br/>

{| align="right" border="1" cellpadding="2" 
|-
|style="background:#ABCDEF;" align="center"|'''Gene name'''
|''ytmI''
|-
|style="background:#ABCDEF;" align="center"| '''Synonyms''' || '' ''
|-
|style="background:#ABCDEF;" align="center"| '''Essential''' || no 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || sulphur N-acetylase
|-
|style="background:#ABCDEF;" align="center"|'''Function''' || utilization of S-methyl-cysteine 
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29390 snaA]
|-
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/riboflavin.html Riboflavin / FAD]'''
|-
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 20 kDa, 5.508  
|-
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 534 bp, 178 aa 
|-
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[tcyJ]]'', ''[[ascR]]''
|-
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU29390 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU29390 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU29390 DNA_with_flanks]
|-
|colspan="2" | '''Genetic context''' <br/> [[Image:ytmI_context.gif]]
 <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div>
|-
|colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ytmI_3008249_3008785_-1 Expression at a glance]'''&#160;&#160;&#160;{{PubMed|22383849}}<br/>[[Image:ytmI_expression.png|500px|link=http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU29390]]
|-
|}

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= [[Categories]] containing this gene/protein =
{{SubtiWiki category|[[sulfur metabolism]]}}

= This gene is a member of the following [[regulons]] =
{{SubtiWiki regulon|[[CymR regulon]]}},
{{SubtiWiki regulon|[[AscR regulon]]}}

=The gene=

=== Basic information ===

* '''Locus tag:''' BSU29390

===Phenotypes of a mutant ===
* reduced growth with S-methyl cysteine {{PubMed|23944997}}
* the ''[[snaA]] [[snaB]]'' double mutant does not grow with S-methyl cysteine {{PubMed|23944997}}

=== Database entries ===

* '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/ytmIJKLMNO-ytnIJ-ribR-ytnLM.html]

* '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13883]

=== Additional information===




=The protein=

=== Basic information/ Evolution ===

* '''Catalyzed reaction/ biological activity:''' 
** N-acetylation of the amino group of S-methyl cysteine {{PubMed|23944997}}

* '''Protein family:''' acetyltransferase family (according to Swiss-Prot)

* '''Paralogous protein(s):''' [[SnaB]]

=== Extended information on the protein ===

* '''Kinetic information:'''	

* '''Domains:''' 

* '''Modification:'''

* '''Cofactor(s):'''

* '''Effectors of protein activity:'''

* '''[[SubtInteract|Interactions]]:'''

* '''[[Localization]]:'''

=== Database entries ===

* '''Structure:'''	

* '''UniProt:''' [http://www.uniprot.org/uniprot/O34350 O34350]

* '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU29390]

* '''E.C. number:'''

=== Additional information===

=Expression and regulation=
* '''Operon:''' ''[[snaA]]-[[tcyJ]]-[[tcyK]]-[[tcyL]]-[[tcyM]]-[[tcyN]]-[[cmoO]]-[[cmoI]]-[[cmoJ]]-[[ribR]]-[[sndA]]-[[ytnM]]'' {{PubMed|15668000}}

* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ytmI_3008249_3008785_-1 snaA] {{PubMed|22383849}}

* '''[[Sigma factor]]:''' [[SigA]] {{PubMed|15272571}}

* '''Regulation:''' 
** repressed in the presence of cysteine ([[CymR]]) {{PubMed|16109943}}
** induced in the presence of S-methyl-cysteine ([[AscR]]) {{PubMed|23944997}}

* '''Regulatory mechanism:''' 
** [[CymR]]: transcription repression {{PubMed|16109943}}
** [[AscR]]: transcription activation {{PubMed|16109943}}

* '''Additional information:'''

=Biological materials =

* '''Mutant:'''

* '''Expression vector:'''
        
* '''lacZ fusion:'''

* '''GFP fusion:'''

* '''two-hybrid system:''' 

* '''Antibody:'''

=Labs working on this gene/protein=

=Your additional remarks=

=References=

<pubmed>15937167,16109943,15668000,11390694 23944997</pubmed>

[[Category:Protein-coding genes]]