mrpA

168

Na⁺ transporter subunit of the Na⁺/H⁺ antiporter, multiple resistance and pH homeostasis

Locus: BSU_31600

Molecular weight: 86.23 kDa

Isoelectric point: 9.52

Protein length: 774 aa

Gene length: 2325 bp

Function: sodium export

Product: Na⁺/H⁺ antiporter subunit

Essential: yes

Synonyms: mrpA, yufT, shaA, ntrA

Genomic Context

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List of homologs in different organisms, belongs to COG2111 (Galperin et al., 2021)

Gene

Coordinates: 3,246,679 → 3,249,003

Phenotypes of a mutant

• essential PubMed
• a ''mrpA'' mutant is viable at pH7.4 and sodium concentrations below 80 mM PubMed
• the ''mrpA'' mutant accumulates internal sodium PubMed

The protein

Catalyzed reaction/ biological activity

• Na  transporter subunit of the Na /H  antiporter PubMed

Protein family

• CPA3 antiporters (TC 2.A.63) subunit A family (single member, according to UniProt)

Structure

• 4HE8 (PDB) (from Thermus thermophilus, 36% identity in a 57% fragment) PubMed
• Q9K2S2 (AlphaFold)

Localization

• inner spore membrane PubMed

Expression and Regulation

Operons

• Genes: mrpA-mrpB-mrpC-mrpD-mrpE-mrpF-mrpG

  Description: PubMed

Biological materials

Mutant

• MGNA-B557 (yufT::erm), available at the NBRP B. subtilis, Japan

References

Reviews

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Original Publications

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