hemE

168

uroporphyrinogen decarboxylase (uroporphyrinogen III)

Locus: BSU_10120

Molecular weight: 39.49 kDa

Isoelectric point: 5.26

Protein length: 353 aa

Gene length: 1062 bp

Function: heme biosynthesis

Product: uroporphyrinogen decarboxylase (uroporphyrinogen III)

Essential: no

E.C.: 4.1.1.37

Synonyms: hemE, uroD

Genomic Context

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List of homologs in different organisms, belongs to COG0407 (Galperin et al., 2021)

Gene

Coordinates: 1,086,117  1,087,178

The protein

Catalyzed reaction/ biological activity

• 4 H⁺ + uroporphyrinogen III --> 4 CO₂ + coproporphyrinogen III (according to UniProt)

Protein family

• uroporphyrinogen decarboxylase family (single member, according to UniProt)

Structure

• 2INF (PDB)
• P32395 (AlphaFold)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: hemE-hemH-hemY

  Description: PubMed

Biological materials

Mutant

• BKE10120 (hemE::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGATTTCCACCTTTCA,  downstream forward: _UP4_TAAGCATATCTTTTGGTATC
• BKK10120 (hemE::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGATTTCCACCTTTCA,  downstream forward: _UP4_TAAGCATATCTTTTGGTATC

References

Reviews

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Original Publications

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