glnM

168

glutamine ABC transporter (membrane protein)

Locus: BSU_27450

Molecular weight: 23.55 kDa

Isoelectric point: 8.42

Protein length: 216 aa

Gene length: 651 bp

Function: glutamine uptake

Product: glutamine ABC transporter (membrane protein)

Essential: no

Synonyms: glnM

Genomic Context

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Categories containing this gene/protein

Cellular processes, Transporters, ABC transporters, Importers, Uptake of amino acids

Metabolism, Amino acid/ nitrogen metabolism, Biosynthesis/ acquisition of amino acids, Biosynthesis/ acquisition of glutamate/ glutamine/ ammonium assimilation

Metabolism, Amino acid/ nitrogen metabolism, Utilization of amino acids, Utilization of glutamine/ glutamate

Lifestyles, Sporulation, Sporulation proteins, Sporulation proteins/ other

Groups of genes, Membrane proteins

List of homologs in different organisms, belongs to COG0765 (Galperin et al., 2021)

This gene is a member of the following regulons

SigE regulon, TnrA regulon

Gene

Coordinates: 2,803,990  2,804,640

The protein

Protein family

Binding-protein-dependent transport system permease family (according to UniProt)

Domains

ABC transmembrane type-1 domain (aa 17-205) (according to UniProt)

Structure

4YMS (PDB) (complex with GlnP; from Thermoanaerobacter tengcongensis , 40% identity) PubMed
O34671 (AlphaFold)

Paralogous protein(s)

GlnP

Localization

cell membrane PubMed

Expression and Regulation

Operons

Genes: glnQ-glnH-glnM-glnP

Description: PubMed

Regulation

expressed during sporulation (SigE) PubMed

Regulatory mechanism

TnrA: activation, PubMed, in tnrA regulon

Sigma factors

SigE: sigma factor, PubMed, in sigE regulon

Biological materials

Mutant

BKE27450 (glnM::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGCCTATTCACTCCTT,  downstream forward: _UP4_AGCTATTGATAAGGAGTGAG
BKK27450 (glnM::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATCTGCCTATTCACTCCTT,  downstream forward: _UP4_AGCTATTGATAAGGAGTGAG

References

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