coaD

168

[metabolite|phosphopantetheine] adenylyltransferase

locus: BSU_15020

Molecular weight: 18.04 kDa

pI: 5.65

Protein length: 161 aa

Gene length: 486 bp

function: biosynthesis of [metabolite|coenzyme A]

product: [metabolite|phosphopantetheine] adenylyltransferase

essential: yes

ec: 2.7.7.3

synonyms: ylbI

List of homologs in different organisms, belongs to COG0669 (Galperin et al., 2021)

Gene

Coordinates: 1,570,078  1,570,563

Phenotypes of a mutant

• essential [Pubmed|28189581]

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The protein

Catalyzed reaction/ biological activity

• [metabolite|ATP] + [metabolite|phosphopantetheine] + H⁺ --> 3'-[metabolite|dephospho-CoA] + [metabolite|diphosphate] (according to UniProt)

Protein family

• bacterial coaD family (single member, according to UniProt)

Structure

• [PDB|1O6B] (complex with ADP)
• [AF|O34797]

[wiki|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|6C9A092F38739A3759793EF8B496569CD02C2E3F|ricF]-[gene|FBD8F0EB241A35747E6398C9AA30D71D6D17CE99|ylbG]-[gene|65FA4B3738C2A5995F019099743C782ADD15C338|ylbH]-[gene|6DAAEF20B68139A732FDCDABD0C420A0C928D373|coaD]

  description: [Pubmed|22383849]

• genes: [gene|65FA4B3738C2A5995F019099743C782ADD15C338|ylbH]-[gene|6DAAEF20B68139A732FDCDABD0C420A0C928D373|coaD]

  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-B360 (ylbI::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1359 NBRP B. subtilis, Japan]

References

• 28189581