TrpP

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Gene name trpP
Synonyms yhaG
Essential no
Product S protein of tryptophan ECF transporter
Function tryptophan uptake
Gene expression levels in SubtiExpress: trpP
Interactions involving this protein in SubtInteract: TrpP
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 18 kDa, 11.155
Gene length, protein length 516 bp, 172 aa
Immediate neighbours yhzF, serC
Sequences Protein DNA DNA_with_flanks
Genetic context
YhaG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
TrpP expression.png















Categories containing this gene/protein

ECF transporter, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

TRAP regulon

The gene

Basic information

  • Locus tag: BSU10010

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: trpP transporter family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced in the absence of tryptophan (MtrB) PubMed
  • Regulatory mechanism:
    • MtrB: translation inhibition at an RNA switch, the MtrB binding site overlaps the Shine-DAlgarno sequence and translation initation region, MtrB binds in the presence of tryptophan PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229] [WorldCat.org] [DOI] (I p)

Original publications

Helen Yakhnin, Hong Zhang, Alexander V Yakhnin, Paul Babitzke
The trp RNA-binding attenuation protein of Bacillus subtilis regulates translation of the tryptophan transport gene trpP (yhaG) by blocking ribosome binding.
J Bacteriol: 2004, 186(2);278-86
[PubMed:14702295] [WorldCat.org] [DOI] (P p)

J P Sarsero, E Merino, C Yanofsky
A Bacillus subtilis gene of previously unknown function, yhaG, is translationally regulated by tryptophan-activated TRAP and appears to be involved in tryptophan transport.
J Bacteriol: 2000, 182(8);2329-31
[PubMed:10735881] [WorldCat.org] [DOI] (P p)