rpsL

168

ribosomal protein uS12

Locus: BSU_01100

Molecular weight: 15.00 kDa

Isoelectric point: 11

Protein length: 138 aa

Gene length: 417 bp

Function: translation

Product: ribosomal protein S12 (uS12)

Essential: yes

Synonyms: rpsL, strA, fun

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0048 (Galperin et al., 2021)

Gene

Coordinates: 129,702  130,118

Phenotypes of a mutant

• essential PubMed

The protein

Protein family

• Universal ribosomal protein uS12 family (single member, according to UniProt)

Structure

• 3J9W (PDB) (the ribosome) PubMed
• P21472 (AlphaFold)

Modification

• phosphorylated on Arg-123 PubMed

Localization

• ribosome (according to UniProt)

Expression and Regulation

Operons

• Genes: rplGB-rpsL-rpsG-fusA-tufA

  Description: PubMed

  Regulation

  • Rel dependent downregulation (Class I) during stringent response PubMed
  • the mRNA is processed between rplGB and rpsL by RNase Y, this requires the RicA-RicF-RicT complex PubMed

  Regulatory mechanism

  • stringent response: negative regulation, PubMed, in stringent response

References

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