sul

168

dihydropteroate synthase

Locus: BSU_00770

Molecular weight: 30.85 kDa

Isoelectric point: 5.36

Protein length: 285 aa

Gene length: 858 bp

Function: biosynthesis of folate

Product: dihydropteroate synthase

Essential: yes

E.C.: 2.5.1.15

Synonyms: sul

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0294 (Galperin et al., 2021)

Gene

Coordinates: 85,737 → 86,594

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate --> diphosphate + dihydropteroate (according to UniProt)

Protein family

• DHPS family (single member, according to UniProt)

Domains

• Pterin-binding domain (aa 25-271) (according to UniProt)

Structure

• 1TWS (PDB) (from B. anthracis, 67.6% identity) PubMed
• 1AJZ (PDB) (from Escherichia coli, 43% identity, 61% similarity) PubMed
• P28822 (AlphaFold)

Localization

• cytoplasm (according to UniProt)

Expression and Regulation

Operons

• Genes: pabB-pabA-pabC-sul-folB-folK-yazB-dusB1-lysS

  Description: PubMed

  Regulation

  • translation repressed by tryptophan (MtrB) PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

References

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