yacC

168

similar to chaperonin (HSP33 Homolog), putative disulfide bond chaperone

Locus: BSU_00710

Molecular weight: 31.66 kDa

Isoelectric point: 4.66

Protein length: 291 aa

Gene length: 876 bp

Function: unknown

Product: putative disulfide bond chaperone

Essential: no

Synonyms: yacC, hslO

Genomic Context

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List of homologs in different organisms, belongs to COG1281 (Galperin et al., 2021)

Gene

Coordinates: 79,880 → 80,755

The protein

Protein family

• HSP33 family (single member, according to UniProt)

Structure

• 1VZY (PDB)
• P37565 (AlphaFold)

Localization

• cytoplasm (according to UniProt)

Expression and Regulation

Operons

• Genes: coaX-yacC-yacD-cysK

  Description: PubMed

  Regulation

  • induced by heat stress (Spx) PubMed

  Regulatory mechanism

  • Spx: activation, PubMed, in spx regulon

  Sigma factors

  • SigM: sigma factor, PubMed, in sigM regulon

• Genes: coaX-yacC

  Description: PubMed

  Sigma factors

  • SigM: sigma factor, PubMed, in sigM regulon

Biological materials

Mutant

• MGNA-B924 (yacC::erm), available at the NBRP B. subtilis, Japan
• BKE00710 (ΔyacC::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TAAATAATCCATTACTAAAC,  downstream forward: _UP4_TAAGCTCTTTAGCGGGTTTT
• BKK00710 (ΔyacC::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_TAAATAATCCATTACTAAAC,  downstream forward: _UP4_TAAGCTCTTTAGCGGGTTTT

References

Research papers

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