aldY

168

aldehyde dehydrogenase (NAD), general stress protein, required for protection against paraquat stress

Locus: BSU_38830

Molecular weight: 52.65 kDa

Isoelectric point: 5.02

Protein length: 485 aa

Gene length: 1458 bp

Function: stress resistance

Product: aldehyde dehydrogenase (NAD)

Essential: no

Synonyms: aldY, yxkE

Genomic Context

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List of homologs in different organisms, belongs to COG1012 (Galperin et al., 2021)

Gene

Coordinates: 3,986,428 → 3,987,885

The protein

Catalyzed reaction/ biological activity

• aldehyde + H₂O + NAD⁺ --> carboxylate + 2 H⁺ + NADH (according to UniProt)

Protein family

• aldehyde dehydrogenase family (according to UniProt)

Structure

• 4DNG (PDB)
• P94358 (AlphaFold)

Paralogous protein(s)

• GbsA, PutC, YcbD, DhaS, RocA, IolA, YwdH, GabD, YfmT, AldX

Expression and Regulation

Operons

• Genes: aldY

  Description: PubMed

  Regulation

  • induced by stress (SigB) PubMed

  Sigma factors

  • SigB: sigma factor, PubMed, in sigB regulon

Biological materials

Mutant

• MGNA-B739 (aldY::erm), available at the NBRP B. subtilis, Japan
• BKE38830 (ΔaldY::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAGATGACCCTCCTTTG,  downstream forward: _UP4_TAAATGAAAAAATCCCTCTG
• BKK38830 (ΔaldY::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATAAGATGACCCTCCTTTG,  downstream forward: _UP4_TAAATGAAAAAATCCCTCTG

References

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