coaE

168

dephospho-CoA kinase

Locus: BSU_29060

Molecular weight: 21.87 kDa

Isoelectric point: 4.86

Protein length: 197 aa

Gene length: 594 bp

Function: synthesis of coenzyme A

Product: dephospho-CoA kinase

Essential: yes

E.C.: 2.7.1.24

Synonyms: ytaG

Genomic Context

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List of homologs in different organisms, belongs to COG0237 (Galperin et al., 2021)

Gene

Coordinates: 2,970,922 → 2,971,515

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• 3'-dephospho-CoA + ATP --> ADP + coenzyme A + H⁺ PubMed

Protein family

• coaE family (single member, according to UniProt)

Domains

• DPCK domain (aa 4-197) (according to UniProt)

Structure

• 1N3B (PDB) (from Escherichia coli, 40% identity, 60% similarity) PubMed
• O34932 (AlphaFold)

Modification

• phosphorylated on ser/ thr/ tyr PubMed

Expression and Regulation

Operons

• Genes: polA-mutM-ytaF-coaE

  Description: PubMed

  Sigma factors

  • SigE: sigma factor, PubMed, in sigE regulon

• Genes: coaE

  Description: PubMed

Biological materials

Mutant

• MGNA-A118 (ytaG::erm), available at the NBRP B. subtilis, Japan

References

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