pyrH

168

uridylate kinase

Locus: BSU_16510

Molecular weight: 25.93 kDa

Isoelectric point: 5.1

Protein length: 240 aa

Gene length: 723 bp

Function: pyrimidine biosynthesis

Product: uridylate kinase

Essential: yes

E.C.: 2.7.4.22

Synonyms: pyrH, smbA

Genomic Context

Hide small RNAsZoom:

List of homologs in different organisms, belongs to COG0528 (Galperin et al., 2021)

Gene

Coordinates: 1,719,802  1,720,524

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• ATP + UMP --> ADP + UDP (according to UniProt)

Protein family

• UMP kinase family (single member, according to UniProt)

Structure

• 2JJX (PDB) (from Bacillus anthracis, 42% identity, 64% similarity) PubMed
• O31749 (AlphaFold)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: rpsB-tsf-pyrH-frr

  Description: PubMed

  Regulation

  • Rel dependent downregulation (Class I) during stringent response PubMed

  Regulatory mechanism

  • stringent response: negative regulation, PubMed, in stringent response

References

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