abh
168
transcriptional regulator of transition state genes
locus
BSU_14480
Molecular weight
10.12 kDa
pI
5.75
function
regulation of gene expression during the transition from growth to stationary phase
product
transcriptional regulator
essential
no
synonyms
abh, ylxT, yzaA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2002 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
1,517,865 1,518,143
Phenotypes of a mutant
inactivation of ''[gene|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh]'' results in sensitivity against beta-lactam antibiotics that can be restored by induction of ''[gene|920F91E748EE079FF864011D9052B073567C41E4|slrR]'' expression or by inactivation of the genes encoding major autolysins (''[gene|6A21293823151C6980BF52B31A4B249A8440F2E1|lytC], [gene|E8B88CBE4F9121DFEEF099D7947CD1E1AE656160|lytF]'') [Pubmed|22211522]
The protein
[wiki|Domains]
[wiki|SpoVT-AbrB domain] (aa 5-50) (according to UniProt)
Structure
[PDB|2FY9] (N-terminal DNA recognition domain)
[AF|P39758]
Paralogous protein(s)
[protein|E5110D9C36E8C55AFD1419987B14A53232165F20|abrB]
[protein|01EF886D3D004EA9B22AC5E75D50FF07D8631E68|spoVT], (only the N-terminal domains (aa 1 through 50) are conserved between SpoVT and the two paralogues)
Expression and Regulation
Operons
genes
[gene|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh]
description
[Pubmed|8002614]
regulation
expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]
sigma factors
[protein|E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX]: sigma factor, [Pubmed|9636707], in [regulon|protein:E77364F274A520FCCA9F5C9504E317B047BA29E6|sigX regulon]
[protein|081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM]: sigma factor, [Pubmed|19465659], in [regulon|protein:081DF3EE9FA56209D648C7677188C61CE3AA8E41|sigM regulon]
[protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]: sigma factor, in [regulon|protein:D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV regulon]
Biological materials
Mutant
BKE14480 ([gene|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14480 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAACCCTTCTTCCTT, downstream forward: _UP4_TAAAATTATGCTAAAAAAGG
BKK14480 ([gene|5872812AB61E92E2944E926915EB7FEE71BFA6D5|abh]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14480 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATAAAAACCCTTCTTCCTT, downstream forward: _UP4_TAAAATTATGCTAAAAAAGG
labs
[wiki|Mark Strauch], Baltimore, USA [http://lifesciences.umaryland.edu/Pages/faculty_profile.aspx?ID=212 homepage]
References
Other original publications
The [wiki|Abh regulon]
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Time of last update: 2024-06-06 11:49:25
Author of last update: Jstuelk