LuxS

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  • Description: S-ribosylhomocysteine lyase, autoinducer-2 production protein, required for swarming motility and the formation of biofilms

Gene name luxS
Synonyms ytjB
Essential no
Product S-ribosylhomocysteine lyase
Function methionine salvage
Metabolic function and regulation of this protein in SubtiPathways:
Cys, Met & Sulfate assimilation
MW, pI 17 kDa, 5.168
Gene length, protein length 471 bp, 157 aa
Immediate neighbours ytkA, ytjA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
LuxS context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU30670

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione (according to Swiss-Prot)
  • Protein family: luxS family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: subject to feedback inhibition PubMed
  • Interactions:
  • Localization:

Database entries

  • Structure: 1JQW (complex with homocysteine), 1J98
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon: luxS
  • Regulation:
  • Regulatory mechanism:
  • Additional information: subject to feedback inhibition PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

M T Hilgers, M L Ludwig
Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site.
Proc Natl Acad Sci U S A: 2001, 98(20);11169-74
[PubMed:11553770] [WorldCat.org] [DOI] (P p)