TreA

From SubtiWiki
Revision as of 21:19, 8 June 2009 by Sroppel (talk | contribs)
Jump to: navigation, search
  • Description: phospho-alpha-glucosidase

Gene name treA
Synonyms treC
Essential no
Product phospho-alpha-glucosidase
Function trehalose utilization
MW, pI 65 kDa, 4.895
Gene length, protein length 1683 bp, 561 aa
Immediate neighbours treP, treR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
TreA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU07810

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate (according to Swiss-Prot)
  • Protein family: glycosyl hydrolase 13 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation: repressed by glucose (CcpA)
  • Regulatory mechanism: CcpA: transcription repression
  • Additional information:

Biological materials

  • Mutant: GP1118 (spc), available in the Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References


  1. Helfert C, Gotsche S, Dahl MK. (1995) Cleavage of trehalose-phosphate in Bacillus subtilis is catalysed by a phospho-alpha-(1-1)-glucosidase encoded by the treA gene. Mol Microbiol. Apr;16(1): 111-120. PubMed