MsrA

From SubtiWiki
Revision as of 12:46, 2 June 2009 by Sroppel (talk | contribs)
Jump to: navigation, search
  • Description: peptide methionine sulfoxide reductase

Gene name msrA
Synonyms yppP
Essential no
Product peptide methionine sulfoxide reductase
Function regeneration of methionine and restoration of protein function after oxidative damage
MW, pI 20 kDa, 5.709
Gene length, protein length 531 bp, 177 aa
Immediate neighbours msrB, ypoP
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MsrA context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:

Additional information

Expression and regulation

  • Regulation: induced by oxidative stress (Spx)
  • Regulatory mechanism: Spx: oxidized Spx binds RpoA and enhances msrA-msrB operon transcription PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed