ATP synthase

The protein complex that couples proton import to ATP synthesis (and alternatively proton export to ATP hydrolysis). The enzyme uses the proton motor force at the membrane for ATP synthesis. It is composed of a integral Fo complex and the attached peripheral F1 complex.

Components of ATP synthase

• the Fo complex: A(1)-B(2)-C(12)
• the F1 complex: alpha(3)-beta(3)-gamma-delta-epsilon

Important original publications

James Martin, Jennifer Hudson, Tassilo Hornung, Wayne D Frasch
Fo-driven Rotation in the ATP Synthase Direction against the Force of F1 ATPase in the FoF1 ATP Synthase.
J Biol Chem: 2015, 290(17);10717-28
[PubMed:25713065] [WorldCat.org] [DOI] (I p)