BceS

• Description: two-component sensor kinase, regulation of bceA-bceB in response to bacitracin, plectasin, mersacidin and actagardine
  
  

Gene name	bceS
Synonyms	ytsB
Essential	no
Product	two-component sensor kinase (OmpR family)
Function	resistance against toxic peptides
Gene expression levels in SubtiExpress: bceS
Interactions involving this protein in SubtInteract: BceS
MW, pI	38 kDa, 5.939
Gene length, protein length	1002 bp, 334 aa
Immediate neighbours	bceA, bceR
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

protein modification, transcription factors and their control, resistance against toxins/ antibiotics, membrane proteins, phosphoproteins

The gene

Basic information

• Locus tag: BSU30390

Database entries

• BsubCyc: BSU30390

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of BceR

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain

• Modification: autophosphorylation on a His residue

• Cofactor(s):

• Effectors of protein activity:
  • binding of BceB in the absence of bacitracin inhibits BceS autophosphorylation PubMed

• Interactions:
  • BceS-BceR PubMed
  • BceB-BceS, in the absence of bacitracin PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• BsubCyc: BSU30390

• Structure:

• UniProt: O35044

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: bceR-bceS PubMed

• Expression browser: bceS PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: