SigD regulon

Regulator	SigD
Overview on the regulons (wiki page) Overview on the regulons (Excel file)

Genes in this regulon

• as-gdpP
• cheV
• cwlQ
• cwlS
• degR
• dltA
• dltB
• dltC
• dltD
• dltE
• epr
• flgB-flgC-fliE-fliF-fliG-fliH-fliI-fliJ-ylxF-fliK-flgD-flgE-fliL-fliM-fliY-cheY-fliZ-fliP-fliQ-fliR-flhB-flhA-flhF-flhG-cheB-cheA-cheW-cheC-cheD-sigD-swrB
• flgK
• flgL
• flgM
• flgN
• flhO
• flhP
• fliD
• fliS
• fliT
• hag
• hemAT
• lytA
• lytB
• lytC
• lytD
• lytF
• mcpA
• mcpB
• mcpC
• motA
• motB
• nfrA
• pgdS
• sigA
• sivC
• tlpA
• tlpB
• tlpC
• ybdO
• yfmS
• yfmT
• yjcP
• yjcQ
• yjfB

• yoaH
• yscB
• yvyC
• yvyF

• ywcH
• yxkC

Comments

• the SigD regulon is strongly overexpressed in a ymdB mutant (loss of bistable gene expression) PubMed
• expression of the SigD regulon is reduced upon overexpression of SlrA, this can be suppressed by mutations in remA, remB, sinR, or slrR PubMed
• expression of the SigD regulon is reduced in pnpA mutants due to reduced sigD expression PubMed
• the SigD regulon is not expressed in a rpsU mutant, this can be suppressed by inactivation of remA PubMed

Important publications on the SigD regulon

Loralyn M Cozy, Andrew M Phillips, Rebecca A Calvo, Ashley R Bate, Yi-Huang Hsueh, Richard Bonneau, Patrick Eichenberger, Daniel B Kearns
SlrA/SinR/SlrR inhibits motility gene expression upstream of a hypersensitive and hysteretic switch at the level of σ(D) in Bacillus subtilis.
Mol Microbiol: 2012, 83(6);1210-28
[PubMed:22329926] [WorldCat.org] [DOI] (I p)

Christine Diethmaier, Nico Pietack, Katrin Gunka, Christoph Wrede, Martin Lehnik-Habrink, Christina Herzberg, Sebastian Hübner, Jörg Stülke
A novel factor controlling bistability in Bacillus subtilis: the YmdB protein affects flagellin expression and biofilm formation.
J Bacteriol: 2011, 193(21);5997-6007
[PubMed:21856853] [WorldCat.org] [DOI] (I p)

Masakuni Serizawa, Hiroki Yamamoto, Hirotake Yamaguchi, Yasutaro Fujita, Kazuo Kobayashi, Naotake Ogasawara, Junichi Sekiguchi
Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses.
Gene: 2004, 329;125-36
[PubMed:15033535] [WorldCat.org] [DOI] (P p)

L M Márquez, J D Helmann, E Ferrari, H M Parker, G W Ordal, M J Chamberlin
Studies of sigma D-dependent functions in Bacillus subtilis.
J Bacteriol: 1990, 172(6);3435-43
[PubMed:2111808] [WorldCat.org] [DOI] (P p)