tagD

168

glycerol-3-phosphate cytidylyltransferase

Locus: BSU_35740

Molecular weight: 15.13 kDa

Isoelectric point: 5.67

Protein length: 129 aa

Gene length: 390 bp

Function: biosynthesis of teichoic acid

Product: glycerol-3-phosphate cytidylyltransferase

Essential: yes

E.C.: 2.7.7.39

Synonyms: tagD

Genomic Context

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List of homologs in different organisms, belongs to COG0615 (Galperin et al., 2021)

Gene

Coordinates: 3,680,581  3,680,970

Phenotypes of a mutant

• essential PubMed
• knockdown of expression results in loss of ICEBs1 conjugation (both in donor and recipient cells) PubMed

The protein

Catalyzed reaction/ biological activity

• CTP + H⁺ + sn-glycerol 3-phosphate --> CDP-glycerol + diphosphate (according to UniProt)

Protein family

• cytidylyltransferase family (with IspD and YfnH, according to UniProt)

Structure

• 1N1D (PDB) (complex with CDP-glycerol) PubMed, 1COZ (PDB)
• P27623 (AlphaFold)

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: tagD-tagE-tagF-tagG-tagH

  Description: PubMed

  Regulation

  • repressed by phosphate (PhoP) PubMed

  Regulatory mechanism

  • PhoP: repression, PubMed, in phoP regulon
  • WalR: activation, PubMed, in walR regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

References

Reviews

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Original Publications

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