GntK

• Description: gluconokinase
  
  

Gene name	gntK
Synonyms
Essential	no
Product	gluconokinase
Function	gluconate utilization
Gene expression levels in SubtiExpress: gntK
Metabolic function and regulation of this protein in SubtiPathways: gntK
MW, pI	56 kDa, 5.517
Gene length, protein length	1539 bp, 513 aa
Immediate neighbours	gntR, gntP
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

AbrB regulon, CcpA regulon, GntR regulon

The gene

Basic information

• Locus tag: BSU40060

Database entries

• BsubCyc: BSU40060

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + D-gluconate = ADP + 6-phospho-D-gluconate (according to Swiss-Prot)

• Protein family: FGGY kinase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• BsubCyc: BSU40060

• Structure:

• UniProt: P12011

• KEGG entry: [3]

• E.C. number: 2.7.1.12

Expression and regulation

• Operon: gntR-gntK-gntP-gntZ PubMed1PubMed2

• Expression browser: gntK PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by gluconate (GntR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • GntR: transcription repression PubMed
  • CcpA: transcription repression PubMed
  • AbrB: transcription activation PubMed

• Additional information:
  • number of protein molecules per cell (complex medium with amino acids, without glucose): 765 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: