MurC

• Description: UDP-N-acetylmuramoyl-L-alanine synthetase
  
  

Gene name	murC
Synonyms	ytxF
Essential	yes PubMed
Product	UDP-N-acetylmuramoyl-L-alanine synthetase
Function	peptidoglycan precursor biosynthesis
Gene expression levels in SubtiExpress: murC
Metabolic function and regulation of this protein in SubtiPathways: murC
MW, pI	48 kDa, 5.307
Gene length, protein length	1296 bp, 432 aa
Immediate neighbours	ytxG, sftA
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

The gene

Basic information

• Locus tag: BSU29790

Phenotypes of a mutant

• essential PubMed
• murC is dispensable in wall-less L-forms PubMed

Database entries

• BsubCyc: BSU29790

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine (according to Swiss-Prot)

• Protein family: murCDEF family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (Homogeneous) PubMed

Database entries

• BsubCyc: BSU29790

• Structure:

• UniProt: P40778

• KEGG entry: [3]

• E.C. number: 6.3.2.8

Expression and regulation

• Operon: murC PubMed

• Expression browser: murC PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Yoshikazu Kawai, Romain Mercier, Jeff Errington
Bacterial cell morphogenesis does not require a preexisting template structure.
Curr Biol: 2014, 24(8);863-7
[PubMed:24704074] [WorldCat.org] [DOI] (I p)

Jean van Heijenoort
Lipid intermediates in the biosynthesis of bacterial peptidoglycan.
Microbiol Mol Biol Rev: 2007, 71(4);620-35
[PubMed:18063720] [WorldCat.org] [DOI] (P p)

Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537] [WorldCat.org] [DOI] (P p)

D Varón, M S Brody, C W Price
Bacillus subtilis operon under the dual control of the general stress transcription factor sigma B and the sporulation transcription factor sigma H.
Mol Microbiol: 1996, 20(2);339-50
[PubMed:8733232] [WorldCat.org] [DOI] (P p)