GerAA

• Description: nutrient receptor, germination response to L-alanine
  
  

Gene name	gerAA
Synonyms
Essential	no
Product	nutrient receptor
Function	germination response to L-alanine
Gene expression levels in SubtiExpress: gerAA
Interactions involving this protein in SubtInteract: GerAA
MW, pI	53 kDa, 8.801
Gene length, protein length	1446 bp, 482 aa
Immediate neighbours	yvzF, gerAB
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

germination, membrane proteins

This gene is a member of the following regulons

SigF regulon, SigG regulon, SpoVT regulon

The gene

Basic information

• Locus tag: BSU33050

Database entries

• BsubCyc: BSU33050

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: gerABKA family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • contains multiple membrane-spanning domains PubMed

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • GerAA-GerAB-GerAC (tentative receptor complex) PubMed
  • GerAA is part of the germinosome in the spore inner membrane PubMed

• Localization:
  • outer surface of the inner spore membrane PubMed

Database entries

• BsubCyc: BSU33050

• Structure:

• UniProt: P07868

• KEGG entry: [3]

• E.C. number:

Additional information

• 1,100 molecules are present per spore PubMed

Expression and regulation

• Operon: gerAA-gerAB-gerAC PubMed

• Expression browser: gerAA PubMed

• Sigma factor: SigG PubMed, SigF PubMed

• Regulation:
  • expressed during sporulation in the forespore (SigF, SigG, SpoVT) PubMed
  • expression level depends on sporulation conditions (medim composition, temperature) PubMed

• Regulatory mechanism:
  • SpoVT: transcription repression PubMed

• Additional information:
  • 1,100 molecules are present per spore PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Kerry-Ann V Stewart, Peter Setlow
Numbers of individual nutrient germinant receptors and other germination proteins in spores of Bacillus subtilis.
J Bacteriol: 2013, 195(16);3575-82
[PubMed:23749970] [WorldCat.org] [DOI] (I p)