cccA

168

cytochrome c550

Locus: BSU_25190

Molecular weight: 12.63 kDa

Isoelectric point: 5.28

Protein length: 120 aa

Gene length: 363 bp

Function: respiration

Product: cytochrome c550

Essential: no

Synonyms: cccA

Genomic Context

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List of homologs in different organisms, belongs to COG2010 (Galperin et al., 2021)

Gene

Coordinates: 2,599,523 → 2,599,885

The protein

Domains

• transmembrane domain at the N-terminus (aa 5 -25) PubMed

Cofactors

• heme c  PubMed

Structure

• P24469 (AlphaFold)

Localization

• cell membrane (outer side) PubMed

Expression and Regulation

Operons

• Genes: cccA

  Description: PubMed

  Regulation

  • carbon catabolite repression (CcpA) PubMed

  Regulatory mechanism

  • CcpA: repression, cre site overlaps -35 region of the promoter PubMed, in ccpA regulon
  • AbrB: repression, PubMed, in abrB regulon

  Sigma factors

  • SigA: sigma factor, PubMed, in sigA regulon

  Additional information

  • the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

Mutant

• BKE25190 (ΔcccA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCCCTTCCCCCTTTTT,  downstream forward: _UP4_TAAAAGAACTATTTTTCTCT
• BKK25190 (ΔcccA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATTTCCCTTCCCCCTTTTT,  downstream forward: _UP4_TAAAAGAACTATTTTTCTCT

References

Reviews

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Original Publications

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