GcvPA

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  • Description: glycine decarboxylase (subunit 1)

Gene name gcvPA
Synonyms yqhJ, gcvP
Essential no
Product glycine decarboxylase (subunit 1)
Function glycine utilization
Gene expression levels in SubtiExpress: gcvPA
MW, pI 49 kDa, 6.947
Gene length, protein length 1344 bp, 448 aa
Immediate neighbours gcvPB, gcvT
Sequences Protein DNA DNA_with_flanks
Genetic context
GcvPA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GcvPA expression.png
























Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

Gly-box

The gene

Basic information

  • Locus tag: BSU24560

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2 (according to Swiss-Prot)
  • Protein family: N-terminal subunit subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • repressed by casamino acids PubMed
    • induced by glycine PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Maumita Mandal, Mark Lee, Jeffrey E Barrick, Zasha Weinberg, Gail Mitchell Emilsson, Walter L Ruzzo, Ronald R Breaker
A glycine-dependent riboswitch that uses cooperative binding to control gene expression.
Science: 2004, 306(5694);275-9
[PubMed:15472076] [WorldCat.org] [DOI] (I p)

Ulrike Mäder, Georg Homuth, Christian Scharf, Knut Büttner, Rüdiger Bode, Michael Hecker
Transcriptome and proteome analysis of Bacillus subtilis gene expression modulated by amino acid availability.
J Bacteriol: 2002, 184(15);4288-95
[PubMed:12107147] [WorldCat.org] [DOI] (P p)