ParE

• Description: subunit of DNA topoisomerase IV
  
  

Gene name	parE
Synonyms	grlB
Essential	yes PubMed
Product	subunit of DNA topoisomerase IV
Function	chromosome segregation and compaction
Gene expression levels in SubtiExpress: parE
MW, pI	72 kDa, 6.166
Gene length, protein length	1965 bp, 655 aa
Immediate neighbours	yneT, parC
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA condensation/ segregation, essential genes

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

• Locus tag: BSU18090

Phenotypes of a mutant

essential PubMed

Database entries

• BsubCyc: BSU18090

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: type II topoisomerase family (according to Swiss-Prot)

• Paralogous protein(s): GyrB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • Nucleoid (Homogeneous) PubMed
  • uniformly distributed throughout the cell PubMed

Database entries

• BsubCyc: BSU18090

• Structure:

• UniProt: Q59192

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: parE-parC PubMed

• Expression browser: parE PubMed

• Sigma factor:

• Regulation:
  • induced by DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: