MraW

• Description: S-adenosyl-L-methionine-dependent methyltransferase
  
  

Gene name	mraW
Synonyms	yllC, ylxA
Essential	no
Product	S-adenosyl-L-methionine-dependent methyltransferase
Function	unknown
Gene expression levels in SubtiExpress: mraW
MW, pI	35 kDa, 6.027
Gene length, protein length	933 bp, 311 aa
Immediate neighbours	mraZ, ftsL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

poorly characterized/ putative enzymes

The gene

Basic information

• Locus tag: BSU15140

Database entries

• BsubCyc: BSU15140

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: MraW family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU15140

• Structure: 1N2X (the protein from Thermotoga maritima, 41% identity, 70% similarity) PubMed

• UniProt: Q07876

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mraZ-mraW-ftsL-pbpB PubMed

• Expression browser: mraW PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:
  • 1A818 ( mraW::erm), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Darcie J Miller, Nancy Ouellette, Elena Evdokimova, Alexei Savchenko, Aled Edwards, Wayne F Anderson
Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain.
Protein Sci: 2003, 12(7);1432-42
[PubMed:12824489] [WorldCat.org] [DOI] (P p)

R A Daniel, A M Williams, J Errington
A complex four-gene operon containing essential cell division gene pbpB in Bacillus subtilis.
J Bacteriol: 1996, 178(8);2343-50
[PubMed:8636036] [WorldCat.org] [DOI] (P p)