splA

168

transcriptional repressor of the spore photoproduct lyase splA-splB operon

Locus: BSU_13920

Molecular weight: 9.08 kDa

Isoelectric point: 4.42

Protein length: 79 aa

Gene length: 240 bp

Function: regulation of the splA-splB operon

Product: transcriptional regulator

Essential: no

Synonyms: splA, ykxI

Genomic Context

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Categories containing this gene/protein

Information processing, Genetics, DNA repair/ recombination

Information processing, Genetics, DNA repair/ recombination, Other proteins

Information processing, Regulation of gene expression, Transcription factors and their control, Transcription factors/ other

Lifestyles, Sporulation, Sporulation proteins, Sporulation proteins/ other

List of homologs in different organisms

This gene is a member of the following regulons

SigG regulon, SplA regulon

Gene

Coordinates: 1,461,453  1,461,692

The protein

Structure

P37955 (AlphaFold)

Expression and Regulation

Operons

Genes: splA-splB

Description: PubMed

Regulation

expressed during sporulation in the forespore (SigG) PubMed

Regulatory mechanism

SplA: negative autoregulation, in splA regulon

Sigma factors

SigG: sigma factor, PubMed, in sigG regulon

Biological materials

Mutant

BKE13920 (splA::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACTATCCCTCCTAGCCA,  downstream forward: _UP4_TAACAAGGAAATCATTACAA
BKK13920 (splA::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATACTATCCCTCCTAGCCA,  downstream forward: _UP4_TAACAAGGAAATCATTACAA

References

Reviews

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Original Publications

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Structure of the spore photoproduct lesion in DNA

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