SipV

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  • Description: signal peptidase I

Gene name sipV
Synonyms yhjF
Essential no
Product signal peptidase I
Function protein secretion
Gene expression levels in SubtiExpress: sipV
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 18 kDa, 10.121
Gene length, protein length 504 bp, 168 aa
Immediate neighbours yhjE, yhjG
Sequences Protein DNA DNA_with_flanks
Genetic context
SipV context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SipV expression.png















Categories containing this gene/protein

protein secretion, membrane proteins

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

  • Locus tag: BSU10490

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)
  • Protein family: peptidase S26 family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands

Your additional remarks

References

Reviews

Ross E Dalbey, Peng Wang, Jan Maarten van Dijl
Membrane proteases in the bacterial protein secretion and quality control pathway.
Microbiol Mol Biol Rev: 2012, 76(2);311-30
[PubMed:22688815] [WorldCat.org] [DOI] (I p)

Original publications