GabT

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  • Description: gamma-aminobutyrate transaminase, general stress protein

Gene name gabT
Synonyms ycnG
Essential no
Product gamma-aminobutyrate transaminase
Function utilization of gamma-amino butyric acid
Gene expression levels in SubtiExpress: gabT
MW, pI 47 kDa, 5.304
Gene length, protein length 1308 bp, 436 aa
Immediate neighbours gabR, gabD
Sequences Protein DNA DNA_with_flanks
Genetic context
GabT context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GabT expression.png















Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

GabR regulon

The gene

Basic information

  • Locus tag: BSU03900

Phenotypes of a mutant

    • growth defect in the presence of gamma-aminobutyrate PubMed
    • no growth with gamma-aminobutyrate as single carbon source PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

  • the protein was reported to be involved in norspermidine production and biofilm disassembly PubMed; however, this is not the case PubMed

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate (according to Swiss-Prot)
    • the protein was reported to be involved in norspermidine production and biofilm disassembly PubMed; however, this is not the case PubMed
  • Protein family: class-III pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expressed in the presence of gamma-butyric acid and pyridoxal 5'-phosphate (GabR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

Your additional remarks

References