Vpr

• Description: minor extracellular serine protease
  
  

Gene name	vpr
Synonyms	ipa-45r
Essential	no
Product	minor extracellular serine protease
Function	protein degradation
Gene expression levels in SubtiExpress: vpr
MW, pI	85 kDa, 5.773
Gene length, protein length	2418 bp, 806 aa
Immediate neighbours	ywcI, ywcH
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of nitrogen sources other than amino acids, proteolysis

This gene is a member of the following regulons

LexA regulon, PhoP regulon

The gene

Basic information

• Locus tag: BSU38090

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase S8 family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:

• Localization:
  • extracellular (signal peptide) PubMed

Database entries

• Structure:

• UniProt: P29141

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: vpr PubMed

• Expression browser: vpr PubMed

• Sigma factor:

• Regulation:
  • expressed under conditions of phosphate limitation (PhoP) PubMed
  • repressed when no DNA damage is present (LexA) PubMed

• Regulatory mechanism:
  • PhoP: transcription activation PubMed
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Massimiliano Marvasi, Pieter T Visscher, Lilliam Casillas Martinez
Exopolymeric substances (EPS) from Bacillus subtilis: polymers and genes encoding their synthesis.
FEMS Microbiol Lett: 2010, 313(1);1-9
[PubMed:20735481] [WorldCat.org] [DOI] (I p)