Xpt

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  • Description: xanthine phosphoribosyltransferase

Gene name xpt
Synonyms
Essential no
Product xanthine phosphoribosyltransferase
Function purine salvage and interconversion
Gene expression levels in SubtiExpress: xpt
Metabolic function and regulation of this protein in SubtiPathways:
xpt
MW, pI 20 kDa, 5.835
Gene length, protein length 582 bp, 194 aa
Immediate neighbours pbuX, ypwA
Sequences Protein DNA DNA_with_flanks
Genetic context
Xpt context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Xpt expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, membrane proteins

This gene is a member of the following regulons

G-box, PurR regulon

The gene

Basic information

  • Locus tag: BSU22070

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1Y0B, 2FXV (complex with GMP), 1Y27 (the riboswitch in complex with guanine)
  • KEGG entry: [3]

Additional information

  • subject to Clp-dependent proteolysis upon glucose starvation PubMed

Expression and regulation

  • Regulation:
    • repressed in the presence of adenine or adenosine (PurR) PubMed
    • induced in the absence of guanine (G-box) PubMed
  • Regulatory mechanism:
  • Additional information: subject to Clp-dependent proteolysis upon glucose starvation PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion: pGP430 (in pAC7), available in Stülke lab
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References