ThyB

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  • Description: thymidylate synthase B

Gene name thyB
Synonyms
Essential no
Product thymidylate synthase B
Function biosynthesis of thymidine nucleotides
Gene expression levels in SubtiExpress: thyB
Interactions involving this protein in SubtInteract: ThyB
Metabolic function and regulation of this protein in SubtiPathways:
thyB
MW, pI 30 kDa, 6.272
Gene length, protein length 792 bp, 264 aa
Immediate neighbours dfrA, ypjQ
Sequences Protein DNA DNA_with_flanks
Genetic context
ThyB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ThyB expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, phosphoproteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU21820

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
    • phosphorylated on Arg-102 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • weak induction in the presence of glucose (CcpN) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References